USA MLS uitslagen speelronde regular season seizoen 2021
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| Tijd | Minute | Thuis | Voltijd | Ruststand | Uit | analyse |
| 07 Nov 2021 23:25 | FT | Colorado Rapids | 5 - 2 | 2 - 0 | Los Angeles FC | |
| 07 Nov 2021 23:25 | FT | Los Angeles Galaxy | 3 - 3 | 1 - 2 | Minnesota United | |
| 07 Nov 2021 23:25 | FT | Portland Timbers | 3 - 0 | 2 - 0 | Austin Aztex | |
| 07 Nov 2021 23:25 | FT | San Jose Earthquakes | 1 - 1 | 1 - 1 | Dallas | |
| 07 Nov 2021 23:25 | FT | Sporting Kansas City | 0 - 1 | 0 - 0 | Real Salt Lake | |
| 07 Nov 2021 23:25 | FT | Vancouver Whitecaps FC | 1 - 1 | 1 - 1 | Seattle Sounders | |
| 07 Nov 2021 20:45 | FT | Cincinnati | 1 - 2 | 1 - 0 | Atlanta United | |
| 07 Nov 2021 20:30 | FT | Montreal Impact | 0 - 2 | 0 - 0 | Orlando City | |
| 07 Nov 2021 20:30 | FT | Columbus Crew | 2 - 0 | 1 - 0 | Chicago Fire | |
| 07 Nov 2021 20:30 | FT | Nashville Sc | 1 - 1 | 1 - 1 | New York Red Bulls | |
| 07 Nov 2021 20:30 | FT | New England Revolution | 0 - 1 | 0 - 0 | Inter Miami | |
| 07 Nov 2021 20:30 | FT | New York City Fc | 1 - 1 | 0 - 1 | Philadelphia Union | |
| 07 Nov 2021 20:30 | FT | Toronto FC | 1 - 3 | 1 - 3 | Washington DC United | |
| 04 Nov 2021 02:30 | FT | Real Salt Lake | 1 - 3 | 0 - 3 | Portland Timbers | |
| 04 Nov 2021 01:00 | FT | Austin Aztex | 3 - 1 | 2 - 0 | Sporting Kansas City | |
| 03 Nov 2021 23:30 | FT | Montreal Impact | 2 - 0 | 0 - 0 | Houston Dynamo | |
| 03 Nov 2021 23:30 | FT | New York Red Bulls | 0 - 0 | 0 - 0 | Atlanta United | |
| 03 Nov 2021 02:30 | FT | Los Angeles FC | 1 - 1 | 1 - 1 | Vancouver Whitecaps FC | |
| 02 Nov 2021 02:08 | FT | Seattle Sounders | 1 - 1 | 0 - 1 | Los Angeles Galaxy | |
| 31 Oct 2021 23:30 | FT | Philadelphia Union | 2 - 0 | 1 - 0 | Cincinnati | |
| 31 Oct 2021 20:05 | FT | Orlando City | 1 - 1 | 1 - 0 | Nashville Sc | |
| 31 Oct 2021 19:00 | FT | Houston Dynamo | 0 - 1 | 0 - 0 | Colorado Rapids | |
| 31 Oct 2021 17:00 | FT | Minnesota United | 2 - 1 | 2 - 1 | Sporting Kansas City | |
| 31 Oct 2021 01:07 | FT | Dallas | 2 - 1 | 1 - 1 | Austin Aztex | |
| 31 Oct 2021 00:30 | FT | Washington DC United | 1 - 3 | 1 - 1 | Columbus Crew | |
| 30 Oct 2021 23:07 | FT | Atlanta United | 1 - 1 | 1 - 0 | Toronto FC | |
| 30 Oct 2021 21:00 | FT | New York Red Bulls | 1 - 0 | 0 - 0 | Montreal Impact | |
| 30 Oct 2021 20:30 | FT | Real Salt Lake | 3 - 4 | 1 - 2 | San Jose Earthquakes | |
| 30 Oct 2021 18:30 | FT | Inter Miami | 1 - 3 | 0 - 1 | New York City Fc | |
| 28 Oct 2021 03:00 | FT | Portland Timbers | 2 - 0 | 1 - 0 | San Jose Earthquakes | |
| 28 Oct 2021 03:00 | FT | Vancouver Whitecaps FC | 2 - 1 | 1 - 0 | Minnesota United | |
| 28 Oct 2021 01:50 | FT | Sporting Kansas City | 2 - 0 | 1 - 0 | Los Angeles Galaxy | |
| 28 Oct 2021 01:00 | FT | Dallas | 1 - 2 | 1 - 0 | Real Salt Lake | |
| 28 Oct 2021 00:30 | FT | New York City Fc | 1 - 0 | 0 - 0 | Chicago Fire | |
| 28 Oct 2021 00:30 | FT | Washington DC United | 1 - 0 | 1 - 0 | New York Red Bulls | |
| 28 Oct 2021 00:30 | FT | Cincinnati | 3 - 6 | 3 - 2 | Nashville Sc | |
| 28 Oct 2021 00:30 | FT | Columbus Crew | 3 - 2 | 2 - 0 | Orlando City | |
| 28 Oct 2021 00:30 | FT | Atlanta United | 2 - 1 | 0 - 1 | Inter Miami | |
| 28 Oct 2021 00:30 | FT | Toronto FC | 2 - 2 | 0 - 1 | Philadelphia Union | |
| 28 Oct 2021 00:00 | FT | New England Revolution | 1 - 0 | 0 - 0 | Colorado Rapids | |
| 27 Oct 2021 03:30 | FT | Los Angeles FC | 3 - 0 | 2 - 0 | Seattle Sounders | |
| 25 Oct 2021 00:55 | FT | Orlando City | 2 - 2 | 1 - 0 | New England Revolution | |
| 24 Oct 2021 22:05 | FT | Austin Aztex | 2 - 1 | 2 - 0 | Houston Dynamo | |
| 24 Oct 2021 03:00 | FT | San Jose Earthquakes | 1 - 1 | 0 - 0 | Vancouver Whitecaps FC | |
| 24 Oct 2021 03:00 | FT | Los Angeles Galaxy | 2 - 2 | 0 - 2 | Dallas | |
| 24 Oct 2021 02:00 | FT | Colorado Rapids | 2 - 0 | 1 - 0 | Portland Timbers | |
| 24 Oct 2021 01:00 | FT | Minnesota United | 1 - 1 | 0 - 1 | Los Angeles FC | |
| 24 Oct 2021 01:00 | FT | Chicago Fire | 1 - 0 | 1 - 0 | Real Salt Lake | |
| 24 Oct 2021 01:00 | FT | Inter Miami | 5 - 1 | 1 - 1 | Cincinnati | |
| 24 Oct 2021 00:30 | FT | New York City Fc | 6 - 0 | 4 - 0 | Washington DC United | |
| 24 Oct 2021 00:30 | FT | Philadelphia Union | 1 - 0 | 1 - 0 | Nashville Sc | |
| 24 Oct 2021 00:30 | FT | Toronto FC | 1 - 1 | 0 - 0 | Montreal Impact | |
| 23 Oct 2021 23:00 | FT | Columbus Crew | 1 - 2 | 1 - 1 | New York Red Bulls | |
| 23 Oct 2021 20:50 | FT | Seattle Sounders | 1 - 2 | 0 - 1 | Sporting Kansas City | |
| 21 Oct 2021 03:30 | FT | San Jose Earthquakes | 4 - 0 | 0 - 0 | Austin Aztex | |
| 21 Oct 2021 03:00 | FT | Portland Timbers | 2 - 3 | 2 - 0 | Vancouver Whitecaps FC | |
| 21 Oct 2021 02:00 | FT | Colorado Rapids | 1 - 1 | 0 - 0 | Seattle Sounders | |
| 21 Oct 2021 01:30 | FT | Houston Dynamo | 0 - 3 | 0 - 2 | Los Angeles Galaxy | |
| 21 Oct 2021 01:30 | FT | Nashville Sc | 1 - 1 | 0 - 0 | Columbus Crew | |
| 21 Oct 2021 01:00 | FT | Minnesota United | 3 - 2 | 1 - 1 | Philadelphia Union | |
| 21 Oct 2021 01:00 | FT | Dallas | 2 - 3 | 2 - 1 | Los Angeles FC | |
| 21 Oct 2021 00:30 | FT | Washington DC United | 2 - 3 | 0 - 0 | New England Revolution | |
| 21 Oct 2021 00:30 | FT | Orlando City | 1 - 1 | 1 - 0 | Montreal Impact | |
| 21 Oct 2021 00:30 | FT | Atlanta United | 1 - 1 | 1 - 0 | New York City Fc | |
| 21 Oct 2021 00:30 | FT | Cincinnati | 3 - 4 | 2 - 2 | Chicago Fire | |
| 21 Oct 2021 00:30 | FT | Inter Miami | 3 - 0 | 2 - 0 | Toronto FC | |
| 18 Oct 2021 03:00 | FT | Vancouver Whitecaps FC | 2 - 1 | 2 - 1 | Sporting Kansas City | |
| 17 Oct 2021 18:00 | FT | New York Red Bulls | 1 - 0 | 1 - 0 | New York City Fc | |
| 17 Oct 2021 03:30 | FT | Los Angeles Galaxy | 2 - 1 | 0 - 0 | Portland Timbers | |
| 17 Oct 2021 02:30 | FT | Real Salt Lake | 3 - 1 | 1 - 0 | Colorado Rapids | |
| 17 Oct 2021 02:00 | FT | Austin Aztex | 0 - 1 | 0 - 1 | Minnesota United | |
| 17 Oct 2021 01:30 | FT | Houston Dynamo | 2 - 1 | 2 - 1 | Seattle Sounders | |
| 17 Oct 2021 00:30 | FT | Toronto FC | 0 - 2 | 0 - 1 | Atlanta United | |
| 17 Oct 2021 00:30 | FT | Washington DC United | 0 - 0 | 0 - 0 | Nashville Sc | |
| 17 Oct 2021 00:30 | FT | Cincinnati | 0 - 1 | 0 - 1 | Orlando City | |
| 17 Oct 2021 00:00 | FT | New England Revolution | 2 - 2 | 0 - 0 | Chicago Fire | |
| 16 Oct 2021 23:00 | FT | Columbus Crew | 4 - 0 | 2 - 0 | Inter Miami | |
| 16 Oct 2021 20:50 | FT | Los Angeles FC | 3 - 1 | 2 - 0 | San Jose Earthquakes | |
| 16 Oct 2021 18:00 | FT | Montreal Impact | 2 - 2 | 1 - 0 | Philadelphia Union | |
| 10 Oct 2021 21:00 | FT | Minnesota United | 1 - 3 | 1 - 0 | Colorado Rapids | |
| 10 Oct 2021 02:00 | FT | Seattle Sounders | 4 - 1 | 2 - 1 | Vancouver Whitecaps FC | |
| 10 Oct 2021 01:00 | FT | Cincinnati | 1 - 2 | 0 - 1 | Philadelphia Union | |
| 09 Oct 2021 23:08 | FT | New York Red Bulls | 1 - 0 | 1 - 0 | Inter Miami | |
| 04 Oct 2021 03:00 | FT | Seattle Sounders | 3 - 0 | 3 - 0 | Colorado Rapids | |
| 04 Oct 2021 01:00 | FT | Los Angeles Galaxy | 1 - 1 | 1 - 1 | Los Angeles FC | |
| 03 Oct 2021 22:50 | FT | Portland Timbers | 1 - 0 | 0 - 0 | Inter Miami | |
| 03 Oct 2021 21:00 | FT | Sporting Kansas City | 4 - 2 | 2 - 0 | Houston Dynamo | |
| 03 Oct 2021 21:00 | FT | Toronto FC | 3 - 1 | 1 - 1 | Chicago Fire | |
| 03 Oct 2021 21:00 | FT | Philadelphia Union | 3 - 0 | 1 - 0 | Columbus Crew | |
| 03 Oct 2021 16:59 | FT | New York City Fc | 0 - 0 | 0 - 0 | Nashville Sc | |
| 03 Oct 2021 03:00 | FT | Vancouver Whitecaps FC | 3 - 0 | 1 - 0 | San Jose Earthquakes | |
| 03 Oct 2021 01:00 | FT | Dallas | 0 - 0 | 0 - 0 | Minnesota United | |
| 03 Oct 2021 00:30 | FT | Orlando City | 2 - 1 | 1 - 1 | Washington DC United | |
| 03 Oct 2021 00:30 | FT | Cincinnati | 0 - 1 | 0 - 0 | New York Red Bulls | |
| 03 Oct 2021 00:00 | FT | Montreal Impact | 2 - 1 | 0 - 0 | Atlanta United | |
| 02 Oct 2021 20:45 | FT | Austin Aztex | 2 - 1 | 1 - 0 | Real Salt Lake | |
| 30 Sep 2021 03:30 | FT | San Jose Earthquakes | 1 - 3 | 0 - 2 | Seattle Sounders | |
| 30 Sep 2021 03:30 | FT | Los Angeles FC | 1 - 2 | 0 - 1 | Portland Timbers | |
| 30 Sep 2021 02:30 | FT | Real Salt Lake | 2 - 1 | 1 - 0 | Los Angeles Galaxy | |
| 30 Sep 2021 02:00 | FT | Colorado Rapids | 3 - 0 | 1 - 0 | Austin Aztex | |
| 30 Sep 2021 02:00 | FT | Houston Dynamo | 0 - 0 | 0 - 0 | Vancouver Whitecaps FC | |
| 30 Sep 2021 01:30 | FT | Nashville Sc | 2 - 2 | 1 - 0 | Orlando City | |
| 30 Sep 2021 01:00 | FT | Chicago Fire | 2 - 0 | 0 - 0 | New York City Fc | |
| 30 Sep 2021 01:00 | FT | Dallas | 1 - 3 | 0 - 1 | Sporting Kansas City | |
| 30 Sep 2021 00:30 | FT | Washington DC United | 3 - 1 | 2 - 1 | Minnesota United | |
| 30 Sep 2021 00:30 | FT | Montreal Impact | 1 - 4 | 1 - 3 | New England Revolution | |
| 30 Sep 2021 00:30 | FT | New York Red Bulls | 1 - 1 | 1 - 1 | Philadelphia Union | |
| 30 Sep 2021 00:00 | FT | Atlanta United | 1 - 0 | 0 - 0 | Inter Miami | |
| 30 Sep 2021 00:00 | FT | Toronto FC | 3 - 2 | 0 - 1 | Cincinnati | |
| 27 Sep 2021 02:30 | FT | Austin Aztex | 2 - 0 | 0 - 0 | Los Angeles Galaxy | |
| 27 Sep 2021 00:25 | FT | Sporting Kansas City | 1 - 2 | 0 - 1 | Seattle Sounders | |
| 26 Sep 2021 18:05 | FT | Chicago Fire | 0 - 0 | 0 - 0 | Nashville Sc | |
| 26 Sep 2021 03:30 | FT | Portland Timbers | 6 - 1 | 2 - 1 | Real Salt Lake | |
| 26 Sep 2021 03:00 | FT | San Jose Earthquakes | 2 - 0 | 1 - 0 | Los Angeles FC | |
| 26 Sep 2021 03:00 | FT | Vancouver Whitecaps FC | 1 - 0 | 1 - 0 | Dallas | |
| 26 Sep 2021 01:00 | FT | New York City Fc | 0 - 1 | 0 - 1 | New York Red Bulls | |
| 26 Sep 2021 01:00 | FT | Minnesota United | 2 - 0 | 2 - 0 | Houston Dynamo | |
| 26 Sep 2021 01:00 | FT | Colorado Rapids | 0 - 0 | 0 - 0 | Toronto FC | |
| 26 Sep 2021 00:35 | FT | Washington DC United | 4 - 2 | 3 - 0 | Cincinnati | |
| 26 Sep 2021 00:35 | FT | Columbus Crew | 2 - 1 | 1 - 0 | Montreal Impact | |
| 26 Sep 2021 00:05 | FT | New England Revolution | 2 - 1 | 2 - 1 | Orlando City | |
| 25 Sep 2021 20:30 | FT | Philadelphia Union | 1 - 0 | 0 - 0 | Atlanta United | |
| 23 Sep 2021 01:00 | FT | New York Red Bulls | 1 - 1 | 0 - 1 | New York City Fc | |
| 23 Sep 2021 01:00 | FT | Chicago Fire | 2 - 3 | 1 - 1 | New England Revolution | |
| 23 Sep 2021 00:30 | FT | Inter Miami | 1 - 5 | 0 - 2 | Nashville Sc | |
| 20 Sep 2021 02:00 | FT | Colorado Rapids | 1 - 1 | 1 - 1 | Vancouver Whitecaps FC | |
| 20 Sep 2021 00:55 | FT | Portland Timbers | 2 - 1 | 1 - 1 | Los Angeles FC | |
| 19 Sep 2021 21:00 | FT | Philadelphia Union | 3 - 1 | 1 - 0 | Orlando City | |
| 19 Sep 2021 18:00 | FT | Montreal Impact | 2 - 0 | 0 - 0 | Chicago Fire | |
| 19 Sep 2021 02:30 | FT | Real Salt Lake | 1 - 0 | 0 - 0 | Seattle Sounders | |
| 19 Sep 2021 02:30 | FT | Houston Dynamo | 3 - 2 | 2 - 0 | Dallas | |
| 19 Sep 2021 01:00 | FT | Austin Aztex | 3 - 4 | 3 - 1 | San Jose Earthquakes | |
| 19 Sep 2021 01:00 | FT | Minnesota United | 3 - 0 | 2 - 0 | Los Angeles Galaxy | |
| 19 Sep 2021 00:30 | FT | Cincinnati | 1 - 2 | 1 - 1 | New York City Fc | |
| 19 Sep 2021 00:30 | FT | Toronto FC | 2 - 1 | 1 - 0 | Nashville Sc | |
| 19 Sep 2021 00:00 | FT | New England Revolution | 1 - 1 | 0 - 0 | Columbus Crew | |
| 18 Sep 2021 20:30 | FT | Atlanta United | 3 - 2 | 1 - 0 | Washington DC United | |
| 18 Sep 2021 00:00 | FT | Inter Miami | 0 - 4 | 0 - 2 | New York Red Bulls | |
| 16 Sep 2021 03:30 | FT | San Jose Earthquakes | 3 - 4 | 1 - 1 | Real Salt Lake | |
| 16 Sep 2021 03:30 | FT | Los Angeles Galaxy | 1 - 1 | 0 - 1 | Houston Dynamo | |
| 16 Sep 2021 03:00 | FT | Portland Timbers | 2 - 2 | 0 - 0 | Colorado Rapids | |
| 16 Sep 2021 02:00 | FT | Austin Aztex | 1 - 2 | 0 - 0 | Los Angeles FC | |
| 16 Sep 2021 01:30 | FT | Sporting Kansas City | 4 - 0 | 3 - 0 | Minnesota United | |
| 16 Sep 2021 00:30 | FT | Washington DC United | 3 - 0 | 3 - 0 | Chicago Fire | |
| 16 Sep 2021 00:30 | FT | Orlando City | 2 - 4 | 1 - 2 | Montreal Impact | |
| 16 Sep 2021 00:00 | FT | Atlanta United | 4 - 0 | 2 - 0 | Cincinnati | |
| 15 Sep 2021 00:30 | FT | Columbus Crew | 2 - 1 | 0 - 1 | New York Red Bulls | |
| 15 Sep 2021 00:30 | FT | Toronto FC | 0 - 1 | 0 - 0 | Inter Miami | |
| 15 Sep 2021 00:30 | FT | New York City Fc | 3 - 3 | 1 - 1 | Dallas | |
| 13 Sep 2021 03:30 | FT | Los Angeles FC | 3 - 2 | 2 - 1 | Real Salt Lake | |
| 12 Sep 2021 01:38 | FT | Sporting Kansas City | 2 - 0 | 2 - 0 | Chicago Fire | |
| 12 Sep 2021 01:38 | FT | Dallas | 1 - 1 | 0 - 1 | San Jose Earthquakes | |
| 12 Sep 2021 01:30 | FT | Houston Dynamo | 3 - 0 | 2 - 0 | Austin Aztex | |
| 12 Sep 2021 01:00 | FT | Montreal Impact | 0 - 1 | 0 - 0 | Nashville Sc | |
| 12 Sep 2021 01:00 | FT | Cincinnati | 2 - 0 | 1 - 0 | Toronto FC | |
| 12 Sep 2021 01:00 | FT | Inter Miami | 1 - 0 | 1 - 0 | Columbus Crew | |
| 12 Sep 2021 00:00 | FT | New England Revolution | 2 - 1 | 1 - 1 | New York City Fc | |
| 12 Sep 2021 00:00 | FT | New York Red Bulls | 1 - 1 | 1 - 1 | Washington DC United | |
| 11 Sep 2021 22:00 | FT | Seattle Sounders | 1 - 0 | 1 - 0 | Minnesota United | |
| 11 Sep 2021 20:45 | FT | Colorado Rapids | 1 - 1 | 0 - 0 | Los Angeles Galaxy | |
| 11 Sep 2021 03:08 | FT | Vancouver Whitecaps FC | 0 - 1 | 0 - 0 | Portland Timbers | |
| 11 Sep 2021 00:25 | FT | Atlanta United | 3 - 0 | 2 - 0 | Orlando City | |
| 05 Sep 2021 03:07 | FT | San Jose Earthquakes | 0 - 1 | 0 - 0 | Colorado Rapids | |
| 05 Sep 2021 01:07 | FT | Real Salt Lake | 3 - 2 | 1 - 1 | Dallas | |
| 05 Sep 2021 01:07 | FT | Cincinnati | 0 - 1 | 0 - 0 | Inter Miami | |
| 05 Sep 2021 00:37 | FT | Orlando City | 3 - 2 | 2 - 0 | Columbus Crew | |
| 05 Sep 2021 00:08 | FT | Vancouver Whitecaps FC | 2 - 1 | 0 - 1 | Austin Aztex | |
| 04 Sep 2021 03:05 | FT | Los Angeles FC | 4 - 0 | 1 - 0 | Sporting Kansas City | |
| 04 Sep 2021 01:00 | FT | Houston Dynamo | 0 - 2 | 0 - 2 | Portland Timbers | |
| 04 Sep 2021 00:30 | FT | Nashville Sc | 3 - 1 | 2 - 0 | New York City Fc | |
| 04 Sep 2021 00:30 | FT | Philadelphia Union | 0 - 1 | 0 - 1 | New England Revolution | |
| 30 Aug 2021 03:30 | FT | Seattle Sounders | 0 - 2 | 0 - 0 | Portland Timbers | |
| 30 Aug 2021 03:00 | FT | Vancouver Whitecaps FC | 4 - 1 | 1 - 0 | Real Salt Lake | |
| 30 Aug 2021 01:25 | FT | Austin Aztex | 3 - 5 | 1 - 4 | Dallas | |
| 29 Aug 2021 02:00 | FT | Sporting Kansas City | 1 - 1 | 1 - 1 | Colorado Rapids | |
| 29 Aug 2021 02:00 | FT | Houston Dynamo | 1 - 2 | 1 - 1 | Minnesota United | |
| 29 Aug 2021 01:00 | FT | Washington DC United | 3 - 1 | 1 - 1 | Philadelphia Union | |
| 29 Aug 2021 00:30 | FT | New York City Fc | 2 - 0 | 1 - 0 | New England Revolution | |
| 29 Aug 2021 00:00 | FT | Los Angeles FC | 3 - 3 | 1 - 1 | Los Angeles Galaxy | |
| 28 Aug 2021 23:00 | FT | New York Red Bulls | 0 - 1 | 0 - 1 | Chicago Fire | |
| 28 Aug 2021 20:50 | FT | Atlanta United | 0 - 2 | 0 - 1 | Nashville Sc | |
| 28 Aug 2021 01:45 | FT | Orlando City | 0 - 0 | 0 - 0 | Inter Miami | |
| 28 Aug 2021 00:35 | FT | Montreal Impact | 3 - 1 | 1 - 0 | Toronto FC | |
| 27 Aug 2021 23:45 | FT | Columbus Crew | 3 - 2 | 1 - 1 | Cincinnati | |
| 22 Aug 2021 03:00 | FT | Vancouver Whitecaps FC | 2 - 1 | 0 - 1 | Los Angeles FC | |
| 22 Aug 2021 02:05 | FT | Austin Aztex | 3 - 1 | 3 - 0 | Portland Timbers | |
| 22 Aug 2021 02:05 | FT | Colorado Rapids | 2 - 1 | 0 - 0 | Real Salt Lake | |
| 22 Aug 2021 01:45 | FT | Orlando City | 1 - 0 | 0 - 0 | Chicago Fire | |
| 22 Aug 2021 01:30 | FT | Houston Dynamo | 2 - 2 | 1 - 0 | Dallas | |
| 22 Aug 2021 01:00 | FT | Washington DC United | 1 - 2 | 0 - 1 | Atlanta United | |
| 22 Aug 2021 01:00 | FT | New England Revolution | 4 - 1 | 3 - 0 | Cincinnati | |
| 22 Aug 2021 01:00 | FT | Philadelphia Union | 1 - 1 | 0 - 1 | Montreal Impact | |
| 22 Aug 2021 01:00 | FT | Inter Miami | 3 - 1 | 2 - 0 | Toronto FC | |
| 21 Aug 2021 22:55 | FT | Columbus Crew | 1 - 2 | 0 - 0 | Seattle Sounders | |
| 21 Aug 2021 20:30 | FT | Minnesota United | 0 - 0 | 0 - 0 | Sporting Kansas City | |
| 21 Aug 2021 03:30 | FT | Los Angeles Galaxy | 1 - 2 | 0 - 0 | San Jose Earthquakes | |
| 19 Aug 2021 03:08 | FT | Real Salt Lake | 2 - 1 | 1 - 0 | Houston Dynamo | |
| 19 Aug 2021 02:00 | FT | Austin Aztex | 1 - 2 | 1 - 0 | Vancouver Whitecaps FC | |
| 19 Aug 2021 01:30 | FT | Sporting Kansas City | 1 - 1 | 0 - 1 | Portland Timbers | |
| 19 Aug 2021 01:30 | FT | Nashville Sc | 1 - 1 | 1 - 0 | Orlando City | |
| 19 Aug 2021 01:30 | FT | Dallas | 0 - 1 | 0 - 0 | Seattle Sounders | |
| 19 Aug 2021 01:00 | FT | New York Red Bulls | 1 - 0 | 1 - 0 | Columbus Crew | |
| 19 Aug 2021 00:30 | FT | Philadelphia Union | 1 - 0 | 0 - 0 | New York City Fc | |
| 19 Aug 2021 00:30 | FT | Cincinnati | 0 - 0 | 0 - 0 | Montreal Impact | |
| 19 Aug 2021 00:30 | FT | Inter Miami | 3 - 2 | 1 - 1 | Chicago Fire | |
| 19 Aug 2021 00:00 | FT | Atlanta United | 1 - 0 | 1 - 0 | Toronto FC | |
| 19 Aug 2021 00:00 | FT | New England Revolution | 3 - 2 | 0 - 1 | Washington DC United | |
| 18 Aug 2021 03:30 | FT | Los Angeles Galaxy | 1 - 2 | 1 - 1 | Colorado Rapids | |
| 18 Aug 2021 03:30 | FT | San Jose Earthquakes | 1 - 1 | 1 - 1 | Minnesota United | |
| 16 Aug 2021 03:25 | FT | Portland Timbers | 2 - 6 | 1 - 2 | Seattle Sounders | |
| 16 Aug 2021 00:00 | FT | Nashville Sc | 5 - 2 | 3 - 2 | Washington DC United | |
| 15 Aug 2021 23:00 | FT | Chicago Fire | 1 - 0 | 0 - 0 | Columbus Crew | |
| 15 Aug 2021 21:00 | FT | Atlanta United | 1 - 0 | 0 - 0 | Los Angeles FC | |
| 15 Aug 2021 03:08 | FT | Real Salt Lake | 1 - 0 | 1 - 0 | Austin Aztex | |
| 15 Aug 2021 01:30 | FT | Houston Dynamo | 1 - 3 | 1 - 1 | Colorado Rapids | |
| 15 Aug 2021 01:30 | FT | Dallas | 0 - 2 | 0 - 1 | Sporting Kansas City | |
| 15 Aug 2021 01:20 | FT | Montreal Impact | 2 - 1 | 0 - 1 | New York Red Bulls | |
| 15 Aug 2021 01:00 | FT | Toronto FC | 1 - 2 | 0 - 1 | New England Revolution | |
| 15 Aug 2021 01:00 | FT | New York City Fc | 2 - 0 | 2 - 0 | Inter Miami | |
| 14 Aug 2021 23:00 | FT | Minnesota United | 0 - 1 | 0 - 1 | Los Angeles Galaxy | |
| 14 Aug 2021 03:30 | FT | San Jose Earthquakes | 0 - 0 | 0 - 0 | Vancouver Whitecaps FC | |
| 09 Aug 2021 01:00 | FT | Washington DC United | 2 - 1 | 1 - 1 | Montreal Impact | |
| 09 Aug 2021 01:00 | FT | Los Angeles Galaxy | 1 - 1 | 1 - 0 | Vancouver Whitecaps FC | |
| 09 Aug 2021 00:00 | FT | San Jose Earthquakes | 2 - 1 | 2 - 1 | Los Angeles FC | |
| 08 Aug 2021 23:00 | FT | New England Revolution | 2 - 1 | 2 - 1 | Philadelphia Union | |
| 08 Aug 2021 23:00 | FT | Chicago Fire | 2 - 1 | 2 - 0 | New York Red Bulls | |
| 08 Aug 2021 23:00 | FT | Inter Miami | 2 - 1 | 0 - 0 | Nashville Sc | |
| 08 Aug 2021 03:35 | FT | Portland Timbers | 3 - 2 | 2 - 1 | Real Salt Lake | |
| 08 Aug 2021 02:00 | FT | Colorado Rapids | 0 - 0 | 0 - 0 | Sporting Kansas City | |
| 08 Aug 2021 01:30 | FT | Dallas | 2 - 0 | 0 - 0 | Austin Aztex | |
| 08 Aug 2021 01:05 | FT | Minnesota United | 2 - 0 | 1 - 0 | Houston Dynamo | |
| 08 Aug 2021 01:05 | FT | Toronto FC | 2 - 2 | 0 - 2 | New York City Fc | |
| 08 Aug 2021 00:30 | FT | Cincinnati | 1 - 1 | 1 - 0 | Orlando City | |
| 08 Aug 2021 00:30 | FT | Columbus Crew | 2 - 3 | 1 - 2 | Atlanta United | |
| 05 Aug 2021 03:30 | FT | Los Angeles FC | 1 - 4 | 0 - 3 | Sporting Kansas City | |
| 05 Aug 2021 03:30 | FT | Los Angeles Galaxy | 1 - 0 | 0 - 0 | Real Salt Lake | |
| 05 Aug 2021 03:30 | FT | Portland Timbers | 1 - 1 | 1 - 1 | San Jose Earthquakes | |
| 05 Aug 2021 03:05 | FT | Seattle Sounders | 1 - 1 | 0 - 0 | Dallas | |
| 05 Aug 2021 02:05 | FT | Austin Aztex | 3 - 2 | 2 - 1 | Houston Dynamo | |
| 05 Aug 2021 01:00 | FT | Chicago Fire | 0 - 0 | 0 - 0 | New York City Fc | |
| 05 Aug 2021 01:00 | FT | Orlando City | 1 - 1 | 1 - 0 | Inter Miami | |
| 05 Aug 2021 01:00 | FT | New York Red Bulls | 0 - 0 | 0 - 0 | Cincinnati | |
| 05 Aug 2021 00:30 | FT | Columbus Crew | 2 - 4 | 0 - 3 | Washington DC United | |
| 05 Aug 2021 00:30 | FT | Montreal Impact | 2 - 2 | 0 - 0 | Atlanta United | |
| 05 Aug 2021 00:30 | FT | Philadelphia Union | 3 - 0 | 3 - 0 | Toronto FC | |
| 05 Aug 2021 00:00 | FT | New England Revolution | 0 - 0 | 0 - 0 | Nashville Sc | |
| 02 Aug 2021 00:30 | FT | Toronto FC | 1 - 1 | 1 - 1 | Nashville Sc | |
| 01 Aug 2021 23:00 | FT | Philadelphia Union | 1 - 1 | 1 - 1 | Chicago Fire | |
| 01 Aug 2021 03:00 | FT | Vancouver Whitecaps FC | 2 - 2 | 1 - 1 | Minnesota United | |
| 01 Aug 2021 02:00 | FT | Austin Aztex | 0 - 1 | 0 - 1 | Colorado Rapids | |
| 01 Aug 2021 01:30 | FT | Houston Dynamo | 0 - 0 | 0 - 0 | Real Salt Lake | |
| 01 Aug 2021 01:30 | FT | Sporting Kansas City | 1 - 2 | 0 - 1 | Dallas | |
| 01 Aug 2021 01:00 | FT | Inter Miami | 2 - 1 | 0 - 1 | Montreal Impact | |
| 01 Aug 2021 00:30 | FT | Cincinnati | 0 - 0 | 0 - 0 | Washington DC United | |
| 31 Jul 2021 23:00 | FT | New York Red Bulls | 2 - 3 | 1 - 0 | New England Revolution | |
| 31 Jul 2021 22:00 | FT | Seattle Sounders | 0 - 1 | 0 - 1 | San Jose Earthquakes | |
| 31 Jul 2021 03:15 | FT | Los Angeles Galaxy | 4 - 1 | 2 - 1 | Portland Timbers | |
| 31 Jul 2021 01:10 | FT | Orlando City | 3 - 2 | 1 - 1 | Atlanta United | |
| 31 Jul 2021 00:30 | FT | New York City Fc | 4 - 1 | 2 - 0 | Columbus Crew | |
| 29 Jul 2021 03:30 | FT | Los Angeles FC | 2 - 2 | 1 - 0 | Minnesota United | |
| 26 Jul 2021 02:00 | FT | Seattle Sounders | 1 - 3 | 0 - 2 | Sporting Kansas City | |
| 26 Jul 2021 01:00 | FT | Washington DC United | 1 - 0 | 1 - 0 | New York Red Bulls | |
| 26 Jul 2021 00:30 | FT | Inter Miami | 1 - 1 | 0 - 0 | Philadelphia Union | |
| 25 Jul 2021 23:00 | FT | New York City Fc | 5 - 0 | 1 - 0 | Orlando City | |
| 25 Jul 2021 23:00 | FT | New England Revolution | 2 - 1 | 1 - 0 | Montreal Impact | |
| 25 Jul 2021 03:30 | FT | Los Angeles FC | 2 - 2 | 1 - 2 | Vancouver Whitecaps FC | |
| 25 Jul 2021 03:00 | FT | San Jose Earthquakes | 1 - 1 | 1 - 1 | Houston Dynamo | |
| 25 Jul 2021 03:00 | FT | Real Salt Lake | 3 - 0 | 2 - 0 | Colorado Rapids | |
| 25 Jul 2021 01:30 | FT | Dallas | 4 - 0 | 2 - 0 | Los Angeles Galaxy | |
| 25 Jul 2021 01:30 | FT | Nashville Sc | 3 - 0 | 2 - 0 | Cincinnati | |
| 25 Jul 2021 01:00 | FT | Minnesota United | 2 - 1 | 0 - 1 | Portland Timbers | |
| 25 Jul 2021 01:00 | FT | Chicago Fire | 1 - 2 | 0 - 1 | Toronto FC | |
| 24 Jul 2021 20:30 | FT | Atlanta United | 0 - 1 | 0 - 0 | Columbus Crew | |
| 23 Jul 2021 02:45 | FT | Austin Aztex | 0 - 1 | 0 - 0 | Seattle Sounders | |
| 23 Jul 2021 01:25 | FT | Orlando City | 2 - 1 | 1 - 0 | Philadelphia Union | |
| 22 Jul 2021 03:30 | FT | Portland Timbers | 2 - 1 | 1 - 1 | Los Angeles FC | |
| 22 Jul 2021 03:00 | FT | Real Salt Lake | 2 - 2 | 2 - 1 | Los Angeles Galaxy | |
| 22 Jul 2021 02:00 | FT | Colorado Rapids | 2 - 0 | 0 - 0 | Dallas | |
| 22 Jul 2021 01:30 | FT | Sporting Kansas City | 1 - 1 | 0 - 0 | San Jose Earthquakes | |
| 22 Jul 2021 01:25 | FT | Cincinnati | 1 - 1 | 0 - 0 | Atlanta United | |
| 22 Jul 2021 01:00 | FT | Chicago Fire | 2 - 2 | 1 - 0 | Washington DC United | |
| 22 Jul 2021 00:30 | FT | New York City Fc | 1 - 0 | 1 - 0 | Montreal Impact | |
| 22 Jul 2021 00:30 | FT | Toronto FC | 1 - 1 | 0 - 0 | New York Red Bulls | |
| 22 Jul 2021 00:30 | FT | Columbus Crew | 0 - 0 | 0 - 0 | Nashville Sc | |
| 22 Jul 2021 00:30 | FT | Inter Miami | 0 - 5 | 0 - 4 | New England Revolution | |
| 21 Jul 2021 03:00 | FT | Vancouver Whitecaps FC | 0 - 0 | 0 - 0 | Houston Dynamo | |
| 18 Jul 2021 19:05 | FT | Minnesota United | 1 - 0 | 0 - 0 | Seattle Sounders | |
| 18 Jul 2021 03:30 | FT | Portland Timbers | 1 - 0 | 0 - 0 | Dallas | |
| 18 Jul 2021 03:30 | FT | Los Angeles FC | 2 - 1 | 1 - 1 | Real Salt Lake | |
| 18 Jul 2021 03:00 | FT | Vancouver Whitecaps FC | 2 - 1 | 0 - 1 | Los Angeles Galaxy | |
| 18 Jul 2021 02:00 | FT | Colorado Rapids | 1 - 1 | 0 - 1 | San Jose Earthquakes | |
| 18 Jul 2021 01:30 | FT | Nashville Sc | 5 - 1 | 4 - 0 | Chicago Fire | |
| 18 Jul 2021 00:35 | FT | Columbus Crew | 2 - 1 | 1 - 0 | New York City Fc | |
| 18 Jul 2021 00:35 | FT | Montreal Impact | 5 - 4 | 2 - 3 | Cincinnati | |
| 18 Jul 2021 00:35 | FT | Toronto FC | 1 - 1 | 0 - 0 | Orlando City | |
| 18 Jul 2021 00:35 | FT | Philadelphia Union | 2 - 1 | 1 - 0 | Washington DC United | |
| 17 Jul 2021 22:00 | FT | Atlanta United | 0 - 1 | 0 - 1 | New England Revolution | |
| 10 Jul 2021 00:30 | FT | Cincinnati | 2 - 2 | 2 - 1 | Columbus Crew | |
| 09 Jul 2021 01:30 | FT | New York Red Bulls | 1 - 1 | 0 - 0 | Philadelphia Union | |
| 09 Jul 2021 01:30 | FT | Nashville Sc | 2 - 2 | 1 - 1 | Atlanta United | |
| 08 Jul 2021 03:30 | FT | Los Angeles Galaxy | 3 - 1 | 2 - 0 | Dallas | |
| 08 Jul 2021 03:00 | FT | Vancouver Whitecaps FC | 0 - 4 | 0 - 1 | Real Salt Lake | |
| 08 Jul 2021 02:00 | FT | Seattle Sounders | 2 - 0 | 0 - 0 | Houston Dynamo | |
| 08 Jul 2021 02:00 | FT | Austin Aztex | 0 - 2 | 0 - 1 | Los Angeles FC | |
| 08 Jul 2021 02:00 | FT | Colorado Rapids | 2 - 0 | 1 - 0 | Minnesota United | |
| 08 Jul 2021 01:25 | FT | New England Revolution | 2 - 3 | 0 - 3 | Toronto FC | |
| 08 Jul 2021 01:00 | FT | Chicago Fire | 3 - 1 | 1 - 1 | Orlando City | |
| 08 Jul 2021 00:30 | FT | Montreal Impact | 2 - 1 | 1 - 1 | New York City Fc | |
| 05 Jul 2021 03:30 | FT | Los Angeles Galaxy | 0 - 2 | 0 - 0 | Sporting Kansas City | |
| 05 Jul 2021 02:00 | FT | Colorado Rapids | 1 - 1 | 0 - 1 | Seattle Sounders | |
| 05 Jul 2021 01:30 | FT | Dallas | 2 - 2 | 1 - 2 | Vancouver Whitecaps FC | |
| 04 Jul 2021 03:00 | FT | Real Salt Lake | 0 - 1 | 0 - 0 | Los Angeles FC | |
| 04 Jul 2021 02:00 | FT | Houston Dynamo | 1 - 1 | 1 - 1 | Cincinnati | |
| 04 Jul 2021 01:00 | FT | Nashville Sc | 1 - 0 | 1 - 0 | Philadelphia Union | |
| 04 Jul 2021 01:00 | FT | Chicago Fire | 3 - 0 | 2 - 0 | Atlanta United | |
| 04 Jul 2021 01:00 | FT | Minnesota United | 2 - 2 | 1 - 1 | San Jose Earthquakes | |
| 04 Jul 2021 00:30 | FT | Orlando City | 1 - 2 | 0 - 1 | New York Red Bulls | |
| 04 Jul 2021 00:30 | FT | Montreal Impact | 1 - 0 | 1 - 0 | Inter Miami | |
| 03 Jul 2021 22:30 | FT | Washington DC United | 7 - 1 | 3 - 1 | Toronto FC | |
| 03 Jul 2021 22:00 | FT | Columbus Crew | 2 - 2 | 1 - 2 | New England Revolution | |
| 02 Jul 2021 02:40 | FT | Austin Aztex | 4 - 1 | 2 - 1 | Portland Timbers | |
| 28 Jun 2021 02:00 | FT | Dallas | 2 - 1 | 1 - 1 | New England Revolution | |
| 28 Jun 2021 01:20 | FT | Austin Aztex | 0 - 0 | 0 - 0 | Columbus Crew | |
| 27 Jun 2021 23:00 | FT | New York City Fc | 2 - 1 | 0 - 1 | Washington DC United | |
| 27 Jun 2021 20:35 | FT | Atlanta United | 0 - 0 | 0 - 0 | New York Red Bulls | |
| 27 Jun 2021 04:30 | FT | Portland Timbers | 0 - 1 | 0 - 1 | Minnesota United | |
| 27 Jun 2021 03:00 | FT | San Jose Earthquakes | 1 - 3 | 0 - 1 | Los Angeles Galaxy | |
| 27 Jun 2021 02:00 | FT | Seattle Sounders | 2 - 2 | 1 - 0 | Vancouver Whitecaps FC | |
| 27 Jun 2021 01:30 | FT | Nashville Sc | 1 - 1 | 0 - 0 | Montreal Impact | |
| 27 Jun 2021 01:00 | FT | Real Salt Lake | 1 - 1 | 1 - 0 | Houston Dynamo | |
| 27 Jun 2021 01:00 | FT | Chicago Fire | 3 - 3 | 1 - 2 | Philadelphia Union | |
| 27 Jun 2021 00:00 | FT | Toronto FC | 0 - 2 | 0 - 1 | Cincinnati | |
| 26 Jun 2021 22:30 | FT | Sporting Kansas City | 2 - 1 | 0 - 1 | Los Angeles FC | |
| 26 Jun 2021 01:20 | FT | Inter Miami | 1 - 2 | 0 - 0 | Orlando City | |
| 24 Jun 2021 03:40 | FT | Vancouver Whitecaps FC | 1 - 2 | 0 - 0 | Los Angeles Galaxy | |
| 24 Jun 2021 03:30 | FT | Los Angeles FC | 2 - 0 | 1 - 0 | Dallas | |
| 24 Jun 2021 03:00 | FT | Seattle Sounders | 2 - 1 | 0 - 0 | Real Salt Lake | |
| 24 Jun 2021 01:30 | FT | Sporting Kansas City | 3 - 1 | 2 - 0 | Colorado Rapids | |
| 24 Jun 2021 01:30 | FT | Nashville Sc | 3 - 2 | 0 - 1 | Toronto FC | |
| 24 Jun 2021 01:30 | FT | Houston Dynamo | 2 - 2 | 2 - 0 | Portland Timbers | |
| 24 Jun 2021 01:00 | FT | Chicago Fire | 0 - 1 | 0 - 0 | Cincinnati | |
| 24 Jun 2021 01:00 | FT | Montreal Impact | 0 - 0 | 0 - 0 | Washington DC United | |
| 24 Jun 2021 01:00 | FT | Minnesota United | 2 - 0 | 2 - 0 | Austin Aztex | |
| 24 Jun 2021 00:30 | FT | New York City Fc | 1 - 0 | 0 - 0 | Atlanta United | |
| 24 Jun 2021 00:30 | FT | Philadelphia Union | 1 - 0 | 1 - 0 | Columbus Crew | |
| 24 Jun 2021 00:00 | FT | New England Revolution | 3 - 2 | 2 - 0 | New York Red Bulls | |
| 23 Jun 2021 00:55 | FT | Orlando City | 5 - 0 | 3 - 0 | San Jose Earthquakes | |
| 20 Jun 2021 19:10 | FT | Atlanta United | 2 - 2 | 0 - 0 | Philadelphia Union | |
| 20 Jun 2021 04:00 | FT | Los Angeles FC | 1 - 1 | 0 - 0 | Houston Dynamo | |
| 20 Jun 2021 03:30 | FT | Portland Timbers | 2 - 1 | 2 - 1 | Sporting Kansas City | |
| 20 Jun 2021 02:05 | FT | Los Angeles Galaxy | 1 - 2 | 1 - 1 | Seattle Sounders | |
| 20 Jun 2021 02:00 | FT | Austin Aztex | 0 - 0 | 0 - 0 | San Jose Earthquakes | |
| 20 Jun 2021 01:30 | FT | Dallas | 1 - 1 | 0 - 1 | Minnesota United | |
| 20 Jun 2021 01:00 | FT | Washington DC United | 1 - 0 | 0 - 0 | Inter Miami | |
| 20 Jun 2021 00:35 | FT | New York City Fc | 2 - 3 | 0 - 1 | New England Revolution | |
| 20 Jun 2021 00:35 | FT | Cincinnati | 0 - 2 | 0 - 1 | Colorado Rapids | |
| 20 Jun 2021 00:35 | FT | Toronto FC | 2 - 3 | 2 - 2 | Orlando City | |
| 20 Jun 2021 00:35 | FT | Columbus Crew | 2 - 0 | 2 - 0 | Chicago Fire | |
| 19 Jun 2021 03:00 | FT | Real Salt Lake | 3 - 1 | 1 - 0 | Vancouver Whitecaps FC | |
| 19 Jun 2021 01:00 | FT | New York Red Bulls | 2 - 0 | 1 - 0 | Nashville Sc | |
| 12 Jun 2021 20:00 | FT | Sporting Kansas City | 1 - 1 | 0 - 1 | Austin Aztex | |
| 31 May 2021 02:30 | FT | Seattle Sounders | 0 - 0 | 0 - 0 | Austin Aztex | |
| 31 May 2021 00:25 | FT | Philadelphia Union | 3 - 0 | 2 - 0 | Portland Timbers | |
| 30 May 2021 02:30 | FT | Real Salt Lake | 1 - 1 | 1 - 0 | Minnesota United | |
| 30 May 2021 02:00 | FT | Colorado Rapids | 3 - 0 | 2 - 0 | Dallas | |
| 30 May 2021 01:30 | FT | Sporting Kansas City | 3 - 2 | 0 - 1 | Houston Dynamo | |
| 30 May 2021 01:00 | FT | Inter Miami | 0 - 3 | 0 - 2 | Washington DC United | |
| 30 May 2021 00:00 | FT | Los Angeles Galaxy | 1 - 0 | 0 - 0 | San Jose Earthquakes | |
| 29 May 2021 22:00 | FT | Los Angeles FC | 1 - 2 | 0 - 0 | New York City Fc | |
| 29 May 2021 20:35 | FT | Atlanta United | 2 - 2 | 1 - 0 | Nashville Sc | |
| 29 May 2021 20:05 | FT | Columbus Crew | 2 - 1 | 2 - 0 | Toronto FC | |
| 29 May 2021 20:05 | FT | Cincinnati | 0 - 1 | 0 - 0 | New England Revolution | |
| 29 May 2021 18:00 | FT | Chicago Fire | 0 - 1 | 0 - 0 | Montreal Impact | |
| 29 May 2021 18:00 | FT | New York Red Bulls | 2 - 1 | 1 - 0 | Orlando City | |
| 24 May 2021 02:25 | FT | Nashville Sc | 1 - 0 | 1 - 0 | Austin Aztex | |
| 24 May 2021 00:15 | FT | Washington DC United | 0 - 1 | 0 - 1 | Philadelphia Union | |
| 23 May 2021 21:55 | FT | Seattle Sounders | 1 - 1 | 1 - 0 | Atlanta United | |
| 23 May 2021 03:30 | FT | Los Angeles FC | 2 - 1 | 2 - 0 | Colorado Rapids | |
| 23 May 2021 03:00 | FT | San Jose Earthquakes | 1 - 3 | 1 - 1 | Sporting Kansas City | |
| 23 May 2021 02:00 | FT | Houston Dynamo | 2 - 1 | 2 - 0 | Vancouver Whitecaps FC | |
| 23 May 2021 01:00 | FT | New England Revolution | 3 - 1 | 2 - 1 | New York Red Bulls | |
| 23 May 2021 01:00 | FT | Dallas | 2 - 2 | 1 - 1 | Real Salt Lake | |
| 23 May 2021 00:37 | FT | New York City Fc | 1 - 2 | 1 - 0 | Columbus Crew | |
| 23 May 2021 00:00 | FT | Orlando City | 1 - 0 | 1 - 0 | Toronto FC | |
| 22 May 2021 23:05 | FT | Chicago Fire | 1 - 0 | 0 - 0 | Inter Miami | |
| 22 May 2021 20:30 | FT | Portland Timbers | 3 - 0 | 0 - 0 | Los Angeles Galaxy | |
| 22 May 2021 18:00 | FT | Montreal Impact | 1 - 2 | 0 - 0 | Cincinnati | |
| 17 May 2021 02:30 | FT | Seattle Sounders | 2 - 0 | 0 - 0 | Los Angeles FC | |
| 17 May 2021 01:00 | FT | Washington DC United | 0 - 1 | 0 - 1 | Orlando City | |
| 16 May 2021 23:00 | FT | New England Revolution | 1 - 0 | 0 - 0 | Columbus Crew | |
| 16 May 2021 21:30 | FT | Cincinnati | 2 - 3 | 0 - 2 | Inter Miami | |
| 16 May 2021 19:00 | FT | Sporting Kansas City | 3 - 0 | 2 - 0 | Vancouver Whitecaps FC | |
| 16 May 2021 03:00 | FT | San Jose Earthquakes | 0 - 2 | 0 - 1 | Portland Timbers | |
| 16 May 2021 02:30 | FT | Real Salt Lake | 0 - 0 | 0 - 0 | Nashville Sc | |
| 16 May 2021 02:00 | FT | Colorado Rapids | 3 - 1 | 3 - 1 | Houston Dynamo | |
| 16 May 2021 01:05 | FT | Minnesota United | 1 - 0 | 0 - 0 | Dallas | |
| 16 May 2021 00:30 | FT | Philadelphia Union | 1 - 0 | 1 - 0 | New York Red Bulls | |
| 16 May 2021 00:00 | FT | Atlanta United | 1 - 0 | 0 - 0 | Montreal Impact | |
| 15 May 2021 20:50 | FT | Los Angeles Galaxy | 2 - 0 | 1 - 0 | Austin Aztex | |
| 15 May 2021 18:00 | FT | New York City Fc | 1 - 1 | 0 - 0 | Toronto FC | |
| 14 May 2021 01:00 | FT | Washington DC United | 1 - 0 | 1 - 0 | Chicago Fire | |
| 13 May 2021 03:35 | FT | San Jose Earthquakes | 0 - 1 | 0 - 1 | Seattle Sounders | |
| 13 May 2021 02:00 | FT | Minnesota United | 1 - 0 | 0 - 0 | Vancouver Whitecaps FC | |
| 13 May 2021 01:30 | FT | Houston Dynamo | 1 - 0 | 0 - 0 | Sporting Kansas City | |
| 13 May 2021 00:30 | FT | Philadelphia Union | 1 - 1 | 0 - 0 | New England Revolution | |
| 13 May 2021 00:30 | FT | Inter Miami | 0 - 2 | 0 - 2 | Montreal Impact | |
| 13 May 2021 00:00 | FT | Toronto FC | 2 - 0 | 1 - 0 | Columbus Crew | |
| 10 May 2021 00:55 | FT | Sporting Kansas City | 2 - 1 | 0 - 1 | Austin Aztex | |
| 09 May 2021 20:00 | FT | Portland Timbers | 1 - 2 | 0 - 0 | Seattle Sounders | |
| 09 May 2021 18:00 | FT | Inter Miami | 1 - 1 | 0 - 1 | Atlanta United | |
| 09 May 2021 03:00 | FT | Colorado Rapids | 3 - 2 | 0 - 2 | Minnesota United | |
| 09 May 2021 01:00 | FT | Los Angeles Galaxy | 2 - 1 | 1 - 0 | Los Angeles FC | |
| 08 May 2021 23:00 | FT | Orlando City | 1 - 1 | 0 - 0 | New York City Fc | |
| 08 May 2021 20:45 | FT | Dallas | 1 - 1 | 1 - 1 | Houston Dynamo | |
| 08 May 2021 20:00 | FT | Vancouver Whitecaps FC | 2 - 0 | 0 - 0 | Montreal Impact | |
| 08 May 2021 18:30 | FT | Nashville Sc | 2 - 0 | 1 - 0 | New England Revolution | |
| 08 May 2021 18:30 | FT | Columbus Crew | 3 - 1 | 1 - 0 | Washington DC United | |
| 08 May 2021 18:00 | FT | New York Red Bulls | 2 - 0 | 1 - 0 | Toronto FC | |
| 08 May 2021 18:00 | FT | Chicago Fire | 0 - 2 | 0 - 0 | Philadelphia Union | |
| 08 May 2021 02:30 | FT | Real Salt Lake | 1 - 2 | 1 - 0 | San Jose Earthquakes | |
| 03 May 2021 03:05 | FT | Vancouver Whitecaps FC | 0 - 1 | 0 - 1 | Colorado Rapids | |
| 03 May 2021 02:25 | FT | Seattle Sounders | 3 - 0 | 2 - 0 | Los Angeles Galaxy | |
| 02 May 2021 18:00 | FT | Nashville Sc | 0 - 0 | 0 - 0 | Inter Miami | |
| 02 May 2021 04:00 | FT | San Jose Earthquakes | 4 - 1 | 3 - 1 | Washington DC United | |
| 02 May 2021 01:00 | FT | Minnesota United | 0 - 1 | 0 - 1 | Austin Aztex | |
| 02 May 2021 01:00 | FT | Dallas | 4 - 1 | 3 - 0 | Portland Timbers | |
| 02 May 2021 00:30 | FT | Orlando City | 3 - 0 | 2 - 0 | Cincinnati | |
| 02 May 2021 00:30 | FT | Philadelphia Union | 0 - 2 | 0 - 1 | New York City Fc | |
| 02 May 2021 00:00 | FT | New England Revolution | 2 - 1 | 1 - 1 | Atlanta United | |
| 01 May 2021 20:45 | FT | Houston Dynamo | 1 - 1 | 0 - 0 | Los Angeles FC | |
| 01 May 2021 20:00 | FT | Montreal Impact | 0 - 0 | 0 - 0 | Columbus Crew | |
| 01 May 2021 19:00 | FT | Real Salt Lake | 3 - 1 | 1 - 1 | Sporting Kansas City | |
| 01 May 2021 18:00 | FT | New York Red Bulls | 2 - 0 | 0 - 0 | Chicago Fire | |
| 25 Apr 2021 22:55 | FT | Los Angeles Galaxy | 3 - 2 | 2 - 1 | New York Red Bulls | |
| 25 Apr 2021 03:30 | FT | Portland Timbers | 2 - 1 | 1 - 1 | Houston Dynamo | |
| 25 Apr 2021 02:00 | FT | Colorado Rapids | 1 - 3 | 1 - 0 | Austin Aztex | |
| 25 Apr 2021 01:00 | FT | Philadelphia Union | 1 - 2 | 0 - 0 | Inter Miami | |
| 25 Apr 2021 01:00 | FT | Minnesota United | 1 - 2 | 0 - 2 | Real Salt Lake | |
| 25 Apr 2021 01:00 | FT | New England Revolution | 1 - 0 | 0 - 0 | Washington DC United | |
| 25 Apr 2021 01:00 | FT | Atlanta United | 3 - 1 | 1 - 0 | Chicago Fire | |
| 24 Apr 2021 23:00 | FT | Los Angeles FC | 1 - 1 | 1 - 0 | Seattle Sounders | |
| 24 Apr 2021 20:50 | FT | San Jose Earthquakes | 3 - 1 | 1 - 0 | Dallas | |
| 24 Apr 2021 20:00 | FT | Toronto FC | 2 - 2 | 1 - 0 | Vancouver Whitecaps FC | |
| 24 Apr 2021 19:00 | FT | Nashville Sc | 2 - 2 | 0 - 2 | Montreal Impact | |
| 24 Apr 2021 18:00 | FT | New York City Fc | 5 - 0 | 1 - 0 | Cincinnati | |
| 24 Apr 2021 00:55 | FT | Sporting Kansas City | 1 - 1 | 1 - 0 | Orlando City | |
| 19 Apr 2021 03:07 | FT | Vancouver Whitecaps FC | 1 - 0 | 0 - 0 | Portland Timbers | |
| 18 Apr 2021 23:00 | FT | Columbus Crew | 0 - 0 | 0 - 0 | Philadelphia Union | |
| 18 Apr 2021 20:20 | FT | Inter Miami | 2 - 3 | 1 - 0 | Los Angeles Galaxy | |
| 18 Apr 2021 01:30 | FT | Chicago Fire | 2 - 2 | 2 - 2 | New England Revolution | |
| 18 Apr 2021 01:30 | FT | Nashville Sc | 2 - 2 | 1 - 2 | Cincinnati | |
| 18 Apr 2021 01:00 | FT | Washington DC United | 2 - 1 | 2 - 1 | New York City Fc | |
| 18 Apr 2021 01:00 | FT | Dallas | 0 - 0 | 0 - 0 | Colorado Rapids | |
| 18 Apr 2021 01:00 | FT | New York Red Bulls | 1 - 2 | 0 - 0 | Sporting Kansas City | |
| 17 Apr 2021 23:00 | FT | Los Angeles FC | 2 - 0 | 0 - 0 | Austin Aztex | |
| 17 Apr 2021 20:00 | FT | Orlando City | 0 - 0 | 0 - 0 | Atlanta United | |
| 17 Apr 2021 19:00 | FT | Montreal Impact | 4 - 2 | 2 - 1 | Toronto FC | |
| 17 Apr 2021 02:55 | FT | Seattle Sounders | 4 - 0 | 0 - 0 | Minnesota United | |
| 17 Apr 2021 01:05 | FT | Houston Dynamo | 2 - 1 | 1 - 0 | San Jose Earthquakes |
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